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KMID : 1137020230340010003
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Journal of Gynecologic Oncology
2023 Volume.34 No. 1 p.3 ~ p.3
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Contrasting clinical characteristics and treatment patterns in women with newly diagnosed advanced-stage epithelial ovarian cancer in Australia, South Korea and Taiwan
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Chou Hung-Hsueh
DeFazio Anna
Chang Chih-Long
Hsu Heng-Cheng
Jeong Soo-Young
Cheng Wen-Fang
Kim Byoung-Gie
Fereday Sian
Bowtell David
Traficante Nadia
Ariyarantne Dinuka
Tung Teresa
Rajadhyaksha Viraj
Lee Won-Hee
Brown David
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Abstract
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Objective : The real-world INFORM study analyzed sociodemographics, treatment patterns and clinical outcomes for patients with newly diagnosed advanced epithelial ovarian cancer (EOC) in Australia, South Korea (S.Korea) and Taiwan preceding incorporation of poly(ADP-ribose) polymerase inhibitors into clinical practice.
Methods : Retrospective data from patients diagnosed with EOC (high-grade serous EOC for Taiwan) between January 2014 and December 2018 with ≥12 months follow-up from diagnosis were analyzed descriptively. Survival was evaluated by Kaplan-Meier with two-sided 95% confidence interval (CI).
Results : Of the 987 patients (Australia, 223; S.Korea, 513; Taiwan, 251), 98% received platinum-based chemotherapy (CT). In S.Korea and Taiwan 76.0% and 78.9% respectively underwent primary cytoreductive surgery; in Australia, 56.5% had interval debulking surgery. Bevacizumab was included in primary/maintenance therapy for 22.4%, 14.6% and 6.8% of patients in Australia, S.Korea and Taiwan, respectively. Patients receiving bevacizumab were high-risk (reimbursement policy) and achieved similar real-world progression-free survival (PFS) compared with CT only. Overall, the median real-world PFS (months; 95% CI) was similar across Australia (16.0 [14.63?18.08]), S.Korea (17.7 [16.18?19.27]) and Taiwan (19.1 [17.56?22.29]).
Conclusion : This study reveals poor prognosis despite differences in demographics and treatment patterns for patients with EOC across Asia-Pacific suggesting the need for biomarker-driven novel therapies to improve outcomes.
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KEYWORD
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Ovarian Cancer, Surgery, Adjuvant Chemotherapy, Neoadjuvant Chemotherapy, Bevacizumab, Maintenance Therapy
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